国际眼科纵览 ›› 2023, Vol. 47 ›› Issue (1): 47-52.doi: 10.3760/ cma.j.issn.1673-5803.2023.01.009

• 综述 • 上一篇    下一篇

纳米制剂改良抗真菌药物治疗真菌性角膜炎的研究进展

黄悦 李妍 李玉婷 包郑伊琳 喻永沅 胡竹林   

  1. 云南大学附属医院眼科 云南省第二人民医院眼科 云南省眼科医院 昆明医科大学第四附属医院眼科 云南省眼科研究所 云南省眼部疾病临床医学研究中心 云南省眼病临床医学中心 云南省眼科疾病研究重点实验室,昆明 650021
  • 收稿日期:2022-05-24 出版日期:2023-02-22 发布日期:2023-03-11
  • 通讯作者: 胡竹林,Email:hzl77@263.net E-mail:hzl77@263.net
  • 基金资助:
    昆医联合专项(202001AY070001-165);云南省卫生健康委员会医学领军人才培养计划(L-2019029);云南省基础研究专项(202201AT070073)

Progress on treatment of fungal keratitis with nano preparation improved antifungal drugs

Huang Yue,Li Yan,Li Yuting,Bao Zheng Yilin,Yu Yongyuan,Hu Zhulin   

  1. Department of Ophthalmology, Affiliated Hospital of Yunnan University; The Second People’s Hospital of Yunnan Province; Yunnan Eye Hospital; Fourth Affiliated Hospital of Kunming Medical University; Yunnan Eye Institute; Yunnan Clinical Medical Research Center of Eye Diseases; Yunnan Clinical Medical Center of Eye Diseases; Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmology, Kunming 650021, China
  • Received:2022-05-24 Online:2023-02-22 Published:2023-03-11
  • Contact: Hu Zhulin, Email: hzl77@263.net E-mail:hzl77@263.net
  • Supported by:
    Association Foundation Program of Yunnan Province Science and Technology Department and Kunming Medical University (202001AY070001-165); Yunnan Provincial Health Commission Medical Leading Talents Training Plan(L-2019029);Yunnan Basic Research Project(202201AT070073)

摘要: 真菌性角膜炎是一种严重危害视力的眼部疾病,目前抗真菌滴眼液是其主要的治疗方法,但由于抗真菌滴眼液与眼表接触时间短、角膜渗透性差,需频繁使用以保持药物的治疗浓度。但频繁局部使用滴眼液可能导致结膜充血、延迟角膜再上皮化等。近年研究发现纳米制剂是一种很好的眼部给药体系,可有效提高滴眼液的生物利用度,减少滴眼液使用频率。(国际眼科纵览,2023, 47:47-52)

关键词: 纳米制剂, 抗真菌药物, 真菌性角膜炎

Abstract: Fungal keratitis is an eye disease that seriously damages vision. At present, anti-fungal eye drops are the main methods to treat fungal keratitis. However, due to the short contact time between anti-fungal eye drops and eye surface, and poor corneal permeability, eye drops are needed to used frequently to maintain the therapeutic concentration of drugs. Frequent topical use of eye drops may be associated with side effects such as congestion and delayed corneal reepithelialization. In recent years, nanomaterials have been found to be a good eye delivery system, which can effectively improve the bioavailability of eye drops and reduce the frequency of eye drops. (Int Rev Ophthalmol, 2023, 47: 47-52)

Key words: nano preparation, antifungal drugs, fungal keratitis